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PATRICK DE BAETSELIER

Tel.: +32-(0)2-629 19 79
Fax.: +32-(0)2-629 19 81
Email: pdebaets@vub.ac.be

Training and positions

  • PhD: Vrije Universiteit Brussel, Brussels, Belgium, 1977
  • Postdoc: Weizmann Institute, Rehovot, Israël, 1977-1980
  • VIB Group leader since 1995
  • Ordinary professor at Vrije Universiteit Brussel since 1997
  • Dean of Faculty of Science Vrije Universiteit Brussel since 2008

Research

  • Research in Patrick De Baetselier's group has historically been focused on cellular immunology, mainly in the context of tumor biology and later on also parasitology. The basic themes comprise the analysis of immune escape mechanisms as well as the mechanisms involved in the invasive and metastatic behavior of cancer cells [1].
  • Since then, the cellular work has been broadened to include the molecular-genetic analysis of both tumor-host and parasite-host interactions [2].
  • The immunobiology of myeloid cells, in particular macrophages, has in the last years grown to be a central research topic, linking investigations in parasitology, tumor immunology and comparative immunology. Based on a coordinated functional genomics analysis of myeloid cells elicited in vivo in a range of diseases and disease models (either developed within our group or available through collaborations), we are (i) addressing the genetic, phenotypic and functional heterogeneity of myeloid cells in different activation states, (ii) elucidating regulatory pathways that underlie the induction and effector activity of these cells and (iii) validating the role of these cells and the associated gene products in the outcome of immune responses in the diseases and disease models under study. In this context, the group has pioneered the molecular and functional characterization of in vivo elicited type 2 cytokine-associated (M2) macrophages [3].
  • In parallel, we have started to validate identified myeloid cell markers as molecular targets for in vivo targeting of myeloid cells during cancer and inflammatory disorders (see for example the "Inflammatrack" project).

Links

Selected references

[1]
De Baetselier et al., Nature, 288: 179-181, 1980;
Lucas et al., Science, 263: 814-817, 1994;
Geldhof et al., Cancer Research, 55: 2730-2733, 1995.
[2]
Beschin et al., Nature, 400: 627-628, 1999;
Devoogdt et al., PNAS USA, 100: 5778-5782, 2003.
[3]
Hassanzadeh Ghassabeh et al., Blood, 108: 575-583, 2006;
Van Ginderachter et al., Blood, 108: 525-535, 2006;
Bosschaerts et al., J Immunol, 180: 6168-6175, 2008.

©2011• Cellular and Molecular Immunology • Last update of this page on 25/9/2008